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I am originally from Mumbai, India. I completed my
Masters in Biochemistry in 1994. I worked as a Scientific
Officer for six years (April 1995 – July 2001)
at Hoechst Marion Roussel India Ltd (a multi- national
pharmaceutical company) prior to joining the Roskamp
Institute. I am currently working as a Research Associate
in the Roskamp
Institute, a non-profit organization headed by Dr.
Michael Mullan and my immediate supervisor is Dr. Daniel
Paris (www.rfdn.org). I commenced my Ph.D. in August
2001 at USF and later transferred to FIU in January
2003 with Dr. Ophelia Weeks as my mentor.
My research is mainly focused on understanding the
impact of inflammation and disruption of calcium homeostasis
on Alzheimer’s disease using in-vitro techniques
in human primary culture cells such as microglia, astrocytes
and neurons. My seminal paper discusses the role of
beta amyloid in activating microglia, the resident macrophages
in the brain and the subsequent release of pro-inflammatory
cytokines and chemokines that may be responsible for
the neurodegeneration observed in Alzheimer’s
disease patients.
The publications I have in this area and a book chapter
that I have written for "Progress in future directions
for COX-2 inhibitors" are listed below.
1. Paris D, Humphrey J, Quadros A, Patel N, Crescentini
R, Crawford F, Mullan M. Vasoactive effects of A beta
in isolated human cerebrovessels and in a transgenic
mouse model of Alzheimer's disease: role of inflammation.
Neurol Res. 2003 Sep; 25(6): 642-51.
2. Quadros A, Patel N, Crescentini R, Crawford F, Paris
D, Mullan M. Increased TNFalpha production and Cox-2
activity in organotypic brain slice cultures from APPsw
transgenic mice. Neurosci Lett. 2003 Dec 15; 353(1):
66-8.
3. Patel NS, Paris D, Mathura V, Quadros AN, Crawford
FC, Mullan MJ. Inflammatory cytokine levels correlate
with amyloid load in transgenic mouse models of Alzheimer's
disease.J Neuroinflammation. 2005 Mar 11;2(1):9.
4. Ait-Ghezala G, Mathura VS, Laporte V, Quadros A,
Paris D, Patel N, Volmar CH, Kolippakkam D, Crawford
F, Mullan M. Genomic regulation after CD40 stimulation
in microglia: relevance to Alzheimer's disease. Brain
Res Mol Brain Res. 2005 Oct 31;140(1-2):73-85.
5. Quadros A., Paris D., Patel N., Mullan M. Effect
of Calcium Channel Blockers on Pro-inflammatory cytokines,
chemokines and prostaglandin release by activated Human
Astrocytes (in preparation).
1. RELEVANCE OF COX-2 INHIBITORS IN ALZHEIMER’S
DISEASE
Amita Quadros, Laila Abdullah, Nikunj Patel, Claude-Henry
Volmar (Novapublishers).
Two micrographs of transgenic mouse brain slices with
double immunostaining for GFAP and 4G8. The astrocytes
are stained red while the amyloid plaques are stained
green (fluorescent dyes).
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