Publications

2.  Perez, R.; Liu, L.; Lopez, J.; An, T.; Rein, K. S. Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates. Marine Drugs 2008, 6, 164-179;

3.  Gantar, M., Berry, John, P., Thomas, Serge, Wang, M., Perez, R., Rein, K. S. Allelopathic activity amongCyanobacteria and microalgae isolated from Florida freshwater habitats, FEMS Microbiol Ecol., 2008; 64 55–64.

4.  An, T.; Kumar, T. K. S.; Wang,  M.; Liu,  L.; Lay, J. O. Jr.; Liyanage, R.; Berry, J.; Gantar,  M.; Marks, V.;  Gawley, R. E.; Rein, K. S. Structures of Pahayokolides A and B, Two Cyclic Peptides from a Lyngbya sp. J. Nat. Prod. (2007) 70, 730-735.

5. Simovic, Dragan; Di, Mingping; Marks, Vered; Chatfield, David C.; Rein, Kathleen S. “1,3-Dipolar Cycloadditions of Trimethylsilyldiazomethane Revisited: Steric Demand of the Dipolarophile and the Influence on Product Distribution.” J. Org. Chem.  (2007), 72(2), 650-653.

6.  Rein, K. S.; Snyder, R. V. “The Biosynthesis of Polyketide Metabolites by Dinoflagellates.” Adv. Appl. Micro. (2006) 59, 93 – 125.

7. Song, Weihua; de la Cruz, Armah A.; Rein, Kathleen; O'Shea, Kevin E.   “Ultrasonically Induced Degradation of Microcystin-LR and -RR: Identification of Products, Effect of pH, Formation and Destruction of Peroxides.”    Environmental Science & Technology (2006),  40(12),  3941-3946.

8. Snyder, Richard V.; Guerrero, Maria A.; Sinigalliano, Christopher D.; Winshell, Jamie; Perez, Roberto; Lopez, Jose V.; Rein, Kathleen S. (2005),   “Localization of polyketide synthase encoding genes to the toxic dinoflagellate Karenia brevis.”    Phytochemistry 66(15),  1767-1780.

9. Song, Weihua; Teshiba, Terri; Rein, Kathleen; O'Shea, Kevin E. (2005), “Ultrasonically Induced Degradation and Detoxification of Microcystin-LR (Cyanobacterial Toxin).” Environmental Science and Technology  39(16),  6300-6305.

10. Rodriguez, J.; Carcache, L. M.; Rein, K. S. (2005) “Residues that influence ligand selectivity in non-NMDA receptors are identified by low-mode docking search.” J. Mol. Recognit. 18:183-189.

11. Berry, J. P.; Gantar, M.; Gawley, R. E.; Wang, M.; Rein, K. S. (2004) “Pharmacology and Toxicology of Pahayokolide A, a Bioactive Metabolite from a Freshwater Species of Lyngbya Isolated from the Florida Everglades.” Comp. Biochem. Phys. Prt C., 139: 231-238.

12. Benson, J. M.; Hutt, J. A.;  Rein, K. S.; Boggs, S. E.;  Barr, E. B.; Fleming, L. E. (2005). “The Toxicity of Microcystin LR in Mice Following Seven Days of Inhalation Exposure.” Toxicon, 45: 691-698.

13. Di, W.; Rein, K. S. (2004) “Aza analogs of kainoids by dipolar cycloaddition” Tetrahedron Lett. 45: 4703-4705.

14. Berry, J. P., Gantar, M.; Gawley, R. E.; Rein, K. S. 2004. Isolation of bioactive metabolites from a Lyngbya species isolated from periphyton of the Florida Everglades. pp. 192-194. In K. A. Steidinger, J. H. Landsberg, C. R. Tomas and G. A. Vargo (eds.) Proceedings of the Xth International Conference on Harmful Algae, October 2002.Florida Fish and Wildlife Conservation Commission, Florida Institute of Oceanography, and Intergovernmental Oceanographic Commission of UNESCO.

15. Carcache, L. M.; Rodriguez, J.; Rein, K. S. (2003) “The Structural Basis for Kainoid Selectivity at AMPA Receptors Revealed by Low-Mode Docking Calculations” Bioorg. Med. Chem. 11: 551-559.

16. Snyder, R. V.; Gibbs, P. D. L.;  Palacios, A.; Abiy, L.; Dickey, R.; Lopez, J. V.; Rein, K. S. (2003) “Polyketide Synthase Genes from Marine Dinoflagellates”.  Mar. Biotech. 5 (1): 1-12.

17. Berry, J. P.; Reece, K. S.; Rein, K. S.; Baden, D. G.; Haas, L. W.; Ribeiro, W. L.; Shields, J. D.; Snyder, R. V.; Vogelbein, W. K.; Gawley, R. E.  (2002) “Are Pfiesteria species toxicogenic? Evidence against production of ichthyotoxins by Pfiesteria shumwayae.”   PNAS, 99 (17), 10970-10975.

18. Purkerson-Parker, S. L.; Fieber, L. A.; Rein, K. S.; Podona, T.; Baden, D. G. (2000) “Brevetoxin Derivatives that Inhibit Toxin Activity” Chem. Biol. 7:385 – 393.

19. Rein, K. S.; Borrone, J. (1999) “Polyketides from Dinoflagellates; Origins, Pharmacology and Biosynthesis”. Comp. Biochem. Phys. Prt B. 124 (2): 117-131

20. Jeglitsch, G.A.; Rein, K. S.; Baden, D. G.; Adams, D.J. (1998) “Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.”  J. Pharmacol. Exp. Ther. 284 (2), 516-525.

21. Brousseau, J.-L.; Vibet, N.; Leblanc, R. M.; Rein, K. S.; Baden, D. G. (1998) “UV-Visible and Inelastic Tunneling Spectroscopies of Brevetoxins.” Applied Spectroscopy, 52: 523-527.

22. Washburn, B. S.; Rein, K. S.; Baden, D. G.; Walsh, P. J.; Hinton, D. E.; Tullis, K.; Dennison, M. S. (1997) “Brevetoxin (PbTx-6), a non-aromatic marine neurotoxin is a ligand of the aryl hydrocarbon receptor.”  Arch. Biochem. Biophys. 343: 149 - 156.

23. Baden, D. G.; Rein, K. S.; Gawley, R. E.; Jeglitsch, G. A; Adams, D. J. (1996) “Marine Toxins: Scientific Approaches, Synthetic Transformations, and Molecular Mechanisms.” Harmfull and Toxic Algal Blooms, 473 - 476, International Oceanographic Commision of UNESCO.

24. Gawley, R. E.; Rein, K. S.; Jeglitsch, G.; Adams, D.J.; Theodorakis, E.A.; Tiebes, J.; Nicolaou, K.C.; Baden, D.G. (1995). “The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels.” Chem. Biol. 8:533-41.

25. Baden, D.G.; Melinek, R.; Sechet, V.; Trainer, V.L.; Schultz, D.R.; Rein, K.S.; Tomas, C.R.; Delgado, J.; and Hale, L.  (1995) “Modified Immunoassays for Polyether Toxins:  Implications of Biological Matrixes, Metabolic States, and Epitope Recognition.” J. Association of Official Analytical Chemists International, 78(2): 499-508.

26. Poli, M.A.; Rein, K.S.; Baden, D.G. (1995) “Radioimmunoassay for the PbTx-2-type brevetoxins: epitopic specificity of two anti-PbTx sera.”  J. Association of Official Analytical Chemists International, 78(2): 538-542.

27. Crouch, Ronald C.; Martin, Gary E.; Dickey, Robert W.; Baden, Daniel G.; Gawley, Robert E.; Rein, Kathleen S.; Mazzola, Eugene P. (1995)   “Brevetoxin-3: total assignment of the 1H and 13C NMR spectra at the submicromole level.”    Tetrahedron,  51(31): 8409-22.

28. Rein, K.S.; Baden, D.G.; Gawley, R.E.  (1994)  “Conformational Analysis of the Sodium Channel Modulator Brevetoxin A, comparison with Brevetoxin B Conformations, and a Hypothesis about the Common Pharmacophore of the “Site 5” Toxins.”  J. Org. Chem. 59: 1959-2101.

29. Rein, K.S.; Lynn, B.; Gawley, R.E.; Baden, D.G. (1994)  “Brevetoxin B:  Chemical Modification, Synaptosome Binding, and Toxicity, an unexpected conformational effect.”  J. Org. Chem.  59: 2107-2113.

30. Melinek, R.; Rein, K.S.; Schultz, D.R.; Baden, D.G. (1994) “Brevetoxin PbTx-2 immunology: differential epitope recognition by antibodies from two goats.”  Toxicon, 32: 883-890.

31. Baden, D.G.; Rein, K.S.; Gawley, R.E.; Jeglitsch, G.; Adams, D.J. (1993) “Is the A-ring Lactone of Brevetoxin PbTx-3 required for Sodium Channel Orphan Receptor Binding and Activity?”  Natural Toxins, 2: 212-221.

32. Gawley, R.E.; Rein, K. S.; Kinoshita, M.; and Baden, D.G. (1992) “Binding of Brevetoxins and Ciguatoxin to the Voltage Sensitive Sodium Channel and Conformational Analysis of Brevetoxin B.” Toxicon, 30: 780-785.

33. Baden D G; Sechet V M; Rein K S; Edwards R A (1992)  “Methods for detecting brevetoxins in seawater, in biological matrices, and on excitable membranes.”    Bull. Soc. Pathol. Exot.  85(5 Pt 2): 516-8. 

34. Rein, K.S., Chen, Z.H., Perumal, P.T., Echegoyen, L.; Gawley, R.E. (1991) "Single Electron Transfer in the Addition of Chiral Dipole-Stabilized Organolithiums to Carbonyls. Sterochemistry of a Chiral Nucleophile as a Mechanistic Probe". Tet.Lett., 32:1941-1944.

35. Rein, K.S.; Gawley, R.E. (1991) "Synthesis of the Phthalideisoquinoline Alkaloids (-)-Egenine, (-)-Corytensine, and (-)-Bicuculline by Asymmetric Carbonyl Addition of Chiral Dipole-Stabilized Organometallics."  J. Org. Chem. 56:1564-1569.

36. Rein, K.S.; Gawley, R.E. (1991) "Analysis of SYMBOL 97 \f "Symbol"-Hydroxybenzyltetrahydroisoquinoline Stereoisomers by Pirkel Column HPLC: Correlation of Absolute Configuration with Order of Elution.” J. Org. Chem. 56:839-841.

37. Rein, K.S.; Gawley, R.E.  (1990)  "Synthesis of (-)-Egenine (Decumbensine) by Asymmetric Carbonyl Addition." Tet.Lett.  31: 3711-3714.

38. Gawley, R. E.; Rein, K. S.; Chemburkar, S. (1989).  "Acyclic Sterioselection in the Alkylation of Chiral Dipole-Stabilized Organolithiums:  A Self-Immolative Chirality Transfer Process for the Synthesis of Primary Amines."  J. Org. Chem.  54: 3002-3004.

39. Rein, K.S.; Giocoechea-Pappas, M.; Anklekar, T.V.; Hart, G.C.; Smith, G.A.; Gawley, R.E. (1989) “Chiral Dipole-Stabilitzed Anions:  Experiment and Theory in Benzylic and Allylic Systems.  Stereoselective Deptotonations, Pyramidal Inversions, and Stereoselective Alkylations of Lithiated (Tetrahydroisoquinolinoyl)oxazolines.” J. Am. Chem. Soc.  111:2211-2217.

40. Idoux, J. P.; Gibbs-Rein, K. S.; Gupton, J. T.; Cunningham, G. N.; “Synthesis and Insecticidal Activity of Some 2,5-(Fluoroalkoxyphenyl)-1,3,4-oxadiazoles and their N,N’-Dibenzoylhydrazine Precursors.” (1988) J. Chem. Eng. Data, 33: 385-388.

41. McLean, A. M.; Babcock-Atkinso,n E.; Rein, K. S.; Ruggirello, D A; Gonzalez, M. A.; Noonan, P. K. (1987). “High-performance liquid chromatographic (HPLC) assay using fluorescence detection for the simultaneous determination of gallopamil and norgallopamil in human plasma.”    Pharm. Res. 4(4): 327-31.