Department of Chemistry & Biochemistry

Florida International University

    Nanjing University, Nanjing, China, 1986, BS,  Biochemistry

The University of Mississippi Medical Center, 1997, PhD, Biochemistry

Postdoctoral research fellow, Johns Hopkins University, 1997-2001

Transcription-Coupled DNA Supercoiling

Protein-DNA Interactions

1. Joynt, S., Morillo, V., and Leng, F. (2009) Binding the Mammalian High Mobility Group Protein AT-hook 2 to AT-Rich Deoxyoligonucleotides: Enthalpy-Entropy Compensation. Biophysical Journal, 96(10):4144-52.

2. Samul, R. and Leng, F. (2007) Transcription-coupled Hypernegative Supercoiling of Plasmid DNA by T7 RNA polymerase in Escherichia coli Topoisomerase I Deficient Strains. Journal of Molecular Biology, 374: 925-35.

3. Cui, T. and Leng, F. (2007) Specific Recognition of AT-Rich DNA Sequences by the Mammalian High Mobility Group Protein AT-hook 2: A SELEX Study. Biochemistry, 46: 13059-66.

4. Cui, T., Wei, S., Brew, K., and Leng, F. (2005) Energetics of Binding the Mammalian High Mobility Group Protein HMGA2 to poly(dA-dT)₂ and poly(dA)poly(dT). Journal of Molecular Biology, 325, 629-645.

5. Leng F, Amado L, & McMacken R. (2004) Coupling DNA Supercoiling to Transcription in Defined Protein Systems. Journal of Biological Chemistry,  279: 47564-71.