Department of Chemistry & Biochemistry

Florida International University

    Nanjing University, Nanjing, China, 1986, BS,  Biochemistry

The University of Mississippi Medical Center, 1997, PhD, Biochemistry

Postdoctoral research fellow, Johns Hopkins University, 1997-2001

Transcription-Coupled DNA Supercoiling

Protein-DNA Interactions

1. Chen, B., Xiao, Y., Liu, C., Li, C., and Leng, F. (2010) DNA Linking Number Change Induced by Sequence-Specific DNA-Binding Proteins. Nucleic Acids Research, in press.

2. Chen, B., Young, J., and Leng, F. (2010) DNA Bending by the Mammalian High Mobility Group Protein AT Hook 2. Biochemistry, in press.

3. Joynt, S., Morillo, V., and Leng, F. (2009) Binding the Mammalian High Mobility Group Protein AT-hook 2 to AT-Rich Deoxyoligonucleotides: Enthalpy-Entropy Compensation. Biophysical Journal, 96(10):4144-52.

4. Samul, R. and Leng, F. (2007) Transcription-coupled Hypernegative Supercoiling of Plasmid DNA by T7 RNA polymerase in Escherichia coli Topoisomerase I Deficient Strains. Journal of Molecular Biology, 374: 925-35.

5. Cui, T. and Leng, F. (2007) Specific Recognition of AT-Rich DNA Sequences by the Mammalian High Mobility Group Protein AT-hook 2: A SELEX Study. Biochemistry, 46: 13059-66.