PUBLICATIONS

36. ≥Aromatic Thiol pKa effects on the Folding Rate of Disulfide Containing Proteins≤

J. D. Gough, J. M. Gargano, A. E. Donofrio, W. J. Lees (2003) Biochemistry, 42, 11787-11797.

35. "New Photochromic Compounds Derived from the Thermolysis of Fluorinated Cycloalkylidene Fulgides"

M. A. Wolak, N. B. Gillespie, R. R. Birge, W. J. Lees (2003) Chem. Commun. 992-993.

34. "Tuning the Optical Properties of Fluorinated Indolylfulgimides"

M. A. Wolak, C. J. Thomas, N. B. Gillespie, R. R. Birge, W. J. Lees (2003) J. Org. Chem., 68, 319-326.

33. "Comparing Structural Properties of a Series of Photochromic Fluorinated Indolylfulgides"

M. A. Wolak, R. C. Finn, C. J. Thomas, R. P. Hammond, R. R. Birge, J. Zubieta, W. J. Lees (2002) Acta Cryst. C, C58, o389-o393.

32. "Folding Disulfide Containing Proteins Faster with an Aromatic Thiol"

J. D. Gough, R. H. Williams Jr., A. E. Donofrio, W. J. Lees (2002) J. Am. Chem. Soc., 124, 3885-3892.

31."Optical and Thermal Properties of Photochromic Fluorinated Adamantylidene Indolylfulgides "

M. A. Wolak, N. B. Gillespie, C. J. Thomas, R. R. Birge, W. J. Lees (2002) J. Photochem. Photobiol. A, 147, 39-44.

30. "Multivalent Inhibition of AB₅ Toxins by Polymers"

J. M. Gargano, T. Ngo, J. Y. Kim, D. W. K. Acheson, W. J. Lees (2001) J. Am. Chem. Soc., 123, 12909-10.

29. "Ionic Blockade of the Rat Connexin40 Gap Junction Channel"

H. Musa, J. D. Gough, W. J. Lees, R. D. Veenstra (2001) Biophysical J. 81, 3253-3274.

28. "Optical Properties of Photochromic Fluorinated Indolylfulgides"

M. A. Wolak, N. R. Gillespie, C. J. Thomas, R. R. Birge, W. J. Lees (2001) J. Photochem. Photobiol. A, 144, 83-91.

27. "Synthesis of an orthogonally protected D-(+)-erythro-sphingosine"

J. M. Gargano, W. J. Lees (2001)Tetrahedron Lett., 42, 5845-5847.

26. "Thermolysis of a Fluorinated Indolylfulgide Features a Novel 1,5-Indolyl Shift"

M. A. Wolak, J. M. Sullivan, C. J. Thomas, R. C. Finn, R. R. Birge, W. J. Lees (2001) J. Org. Chem., 66, 4739-4741.

25. "Effects of Aromatic Thiols on Reactions that Occur During Protein Folding"

T. V. DeCollo W. J. Lees (2001) J. Org. Chem., 66, 4244-4249.

24. "Improved Synthesis of Indolyl Fulgides"

C. J. Thomas, M. A. Wolak, R. R. Birge. W. J. Lees (2001) J. Org. Chem., 66, 1914-1918.

23. "The Stereochemical Course of Enzymatic Enolpyruvyl Transfer and Catalytic Conformation of the Active Site Revealed by the Crystal Structure of the Fluorinated Analog of the Reaction Tetrahedral Intermediate Bound to the Active Site of the C115A Mutant of MurA"

T. Skarzynski, D. H. Kim, W. J. Lees, C. T. Walsh, K. Duncan (1998) Biochemistry, 37, 2572-2577.

22. "Analysis of Fluoromethyl Group Chirality Establishes a Common Stereochemical Course for the Enolpyruvyl Transfers Catalyzed by EPSP Synthase and UDP-GlcNAc Enolpyruvyl Transferase "

D. H. Kim, G. W. Tucker-Kellogg, W. J. Lees, C. T. Walsh (1996) Biochemistry, 35, 5435-5440.

21. "Characterization of a Cys115 to Asp Substitution in the E. coli Cell Wall Biosynthetic Enzyme UDP-GlcNAc Enolpyruvyl Transferase (MurA)That Confers Resistance to Inactivation by the Antibiotic Fosfomycin"

D. H. Kim, W. J. Lees, K. E. Kempsell, W. S. Lane, K. Duncan, C. T. Walsh (1996) Biochemistry, 35, 4923-4928.

20. "The Versatility of Phosphoenolpyruvate and its Vinyl Ether Products in Biosynthesis"

C. T. Walsh, T. E. Benson, D. H. Kim, W. J. Lees (1996) Chem. Biol., 3, 83-91.

19. "(E)-Enolbutyryl-UDP-N-Acetylglucosamine as a Mechanistic Probe of UDP-N-Acetylenolpyruvylglucosamine Reductase (MurB)"

W. J. Lees, T. E. Benson, J. M. Hogle, C. T. Walsh (1996) Biochemistry, 35, 1342-1351.

18. "Acetyl Transfer Precedes Uridylyl Transfer in the Formation of UDP-N-Acetylglucosamine in Separable Active Sites of the Bifunctional GlmU Protein of Escherichia coli"

A. Gehring, W. J. Lees, D. J. Mindiola, C. T. Walsh, E. D. Brown (1996) Biochemistry, 35, 579-585.

17. "Analysis of the Enol Ether Transfer Catalyzed by UDP-GlcNAc Enolpyruvyl Transferase Using (E)- and (Z)- Isomers of Phosphoenolbutyrate: Stereochemical, Partitioning, and Isotope Effect Studies"

W. J. Lees, C. T. Walsh (1995) J. Am. Chem. Soc., 117, 7329-7337.

16. "Stereochemical Analysis of the Tetrahedral Adduct Formed at the Active Site of UDP-GlcNAc Enolpyruvyl Transferase from the Pseudosubstrates, (E)- and (Z)-3-Fluorophosphoenolpyruvate, in D2O"

D. H. Kim, W. J. Lees, C. T. Walsh (1995) J. Am. Chem. Soc., 117, 6380-6381.

15. "Kinetic Characterization of the Inactivation of UDP-GlcNAc Enolpyruvyl Transferase by (Z)-3-Fluorophosphoenolpyruvate: Evidence for Two Oxocarbenium Ion Intermediates in Enolpyruvyl Transfer Catalysis"

D. H. Kim, W. J. Lees, T. M. Haley, C. T. Walsh (1995) J. Am. Chem. Soc., 117, 1494-1502.

14. "Reagents for Rapid Reduction of Disulfide Bonds"

R. Singh, G. V. Lamoureux, W. J. Lees, G. M. Whitesides (1995) Methods Enzymol., 251, 167-173.

13. "Formation of Two Enzyme-Bound Reaction Intermediate Analogs during Inactivation of UDP-GlcNAc Enolpyruvyl Transferase by (E)- or (Z)-3-Fluorophosphoenolpyruvate"

D. H. Kim, W. J. Lees, C. T. Walsh (1994) J. Am. Chem. Soc., 116, 6478-6479.

12. "Using Affinity Capillary Electrophoresis to Determine Binding Stoichiometries of Protein-Ligand Interactions"

Y.-H. Chu, W. J. Lees, A. Stassinopoulos, C. T. Walsh (1994) Biochemistry, 33, 10616-10621.

11. "Polyacrylamides Bearing Pendant a-Sialoside Groups Strongly Inhibit Agglutination of Erythrocytes by Influenza A Virus: Multivalency and Steric Stabilization of Particulate Biological Systems"

W. J. Lees, A. Spaltenstein, J. E. Kingery-Wood, G. M. Whitesides (1994) J. Med. Chem., 37, 3419-3433.

10. "Diastereoselectivity (Enantioselectivity) of Aldol Condensation Catalyzed by Rabbit Muscle Aldolase at C-2 of RCHOHCHO if R Has an Appropriately Placed Negatively Charged Group"

W. J. Lees, G. M. Whitesides (1993) J. Org. Chem., 58, 1887-1894.

9. "Interpretation of the Reduction Potential of 6,6'-Dithiosucrose Cyclic Disulfide by Comparison of the Conformations of 6,6'-Dithiosucrose Cyclic Disulfide, 6,6'-Dithiosucrose, and Sucrose in Aqueous Solution"

W. J. Lees, G. M. Whitesides (1993) J. Am. Chem. Soc., 115, 1860-1869.

8. "Equilibrium Constants for Thiol-Disulfide Interchange Reactions: A Coherent, Corrected Set"

W. J. Lees, G. M. Whitesides (1993) J. Org. Chem., 58, 642-647.

7. "The Enzymatic Synthesis of 1,5-Dideoxy-1,5-diimino-D-talitol and 1-Deoxygalactostatin Using Fuculose-1-phosphate Aldolase"

W. J. Lees, G. M. Whitesides (1992) Bioorg.Chem., 20, 173-179.

6. "Practical Enzyme-Based Syntheses of Uridine 5'-Diphosphogalactose and Uridine 5'-Diphospho-N-acetylgalactosamine on a Gram Scale"

J. Heidlas, W. J. Lees, G. M. Whitesides (1992) J. Org. Chem., 57, 152-157.

5. "Gram-Scale Synthesis of Uridine 5'-Diphospho-N-acetylglucoamine: Comparison of Enzymatic and Chemical Routes"

J. Heidlas, W. J. Lees, P. Pale, G. M. Whitesides (1992) J. Org. Chem., 57, 146-151.

4. "meso-2,5-Dimercapto-N,N,N',N'-tetramethyladipamide: A Readily Available, Kinetically Rapid Reagent for the Reduction of Disulfides in Aqueous Solution"

W. J. Lees, R. Singh, G. M. Whitesides (1991) J. Org. Chem., 56, 7328-7331.

3. "Rabbit Muscle Aldolase as a Catalyst in Organic Synthesis"

M. D. Bednarski, E. S. Simon, N. Bischofberger, W.-D. Fessner, M.-J. Kim, W. J. Lees, T. Saito, H. Waldmann, G. M. Whitesides (1989) J. Am. Chem. Soc., 111, 627-635.

2. "Synthesis of Analogues of 1,3-Dihydroxyacetone Phosphate and Glyceraldehyde 3-Phosphate for Use in Studies of Fructose-1,6-diphosphate Aldolase"

N. Bischofberger, H. Waldmann, T. Saito, E. S. Simon, W. J. Lees, M. D. Bednarski, G. M. Whitesides (1988) J. Org. Chem., 53, 3457-3465.

1. "The aHF and aHFØ Parameters for Spin Polarized Hartree Fock Slater Calculations"

W. J. Lees, S. Manoli, M. A. Whitehead (1985) J. Comp.Chem., 6, 56-60.