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Prem
P. Chapagain, PhD
Assistant
Professor
Department of
Physics
Florida
International University
11200 SW 8th St
CP 204
Miami, FL 33199
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Ph: 305-348-6266
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Fax: 305-348-6700
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Email:
prem.chapagain@fiu.edu
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Research
Highlights: |
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The
Theoretical Biophysics Group at FIU is involved in several research
projects in the area of biological physics. The major projects include
theoretical and computational investigations of protein folding
dynamics, protein
aggregation, and protein engineering. The group
is equipped with
several SGI workstations and a Linux cluster.
I am especially interested in small peptide folding and protien
misfolding. I am also interested in broadly related fields of
biological physics such as mathematical modeling of the dynamics of
infectious diseases, SOC, and complexity.
Recent Publications:
P.
P. Chapagain, Y. Liu, B. S. Gerstman, "The trigger sequence in the GCN4
leucine zipper: alpha-helical propensity and multistate dynamics of
folding and dimerization". Journal of Chemical Physics 129,
175103 (2008). Link
Y. Liu, P. P. Chapagain, J. L. Parra, B. S. Gerstman, “Lattice model
simulation of interchain protein interactions and the folding dynamics
and dimerization of the GCN4 leucine zipper”. Journal of Chemical Physics 128, 045106
(2008). Link
Z.
Lu, R.M. Mitchell, R.L. Smith, P.P. Chapagain, Y.H. Schukken, and Y.T.
Grohn, "The importance of culling in Johne's disease" Journal of
Theoretical Biology 254, 135-146 (2008). Link
C. Lanzas, S. Brien, R. Ivanek, Y. Lo, P.P. Chapagain, K.A. Ray, P. Ayscue, L.D. Warnick, Y.T. Grohn, “The effect of heterogeneous infectious period and contagiousness on the dynamics of Salmonella transmission in dairy cattle”. Epidemioloy and Infection 136, 1496-1510(2008). Link
P. P. Chapagain, J. S. Van Kessel, J. S. Karns, D. Wolfang, E. Hovingh,
K. A. Nelen, Y. H. Schukken, and Y. T. Grohn, “A mathematical model of
the dynamics of Salmonella Cerro infection in a US dairy herd”.
Epidemioloy and Infection 136, 263 (2008). Link
P. P. Chapagain,
J. L. Parra, B. S. Gerstman and Y. Liu, “Sampling of
states for estimating the folding funnel entropy and energy landscape
of a model alpha-helical hairpin peptide” Journal of Chemical Physics
127, 075103 (2007). Link
P. P. Chapagain
and B. S. Gerstman, “Removal of kinetic traps and
enhanced protein folding by strategic substitution of amino acids in a
model α-helical hairpin peptide” Biopolymers 81, 167 (2006). Link
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