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I graduated in July 2001 with an MSc in Biomedical
Science from University of Southampton, England. I am
currently undertaking a PhD degree at the department
of Biological Sciences, Florida International University,
under the supervision of Dr. Ophelia Weeks as my major
professor. My main area of research is concerned with
looking at “The role of the vasculature in Alzheimer’s
disease”. My research is being conducted at the
Roskamp Institute in Sarasota. The Roskamp Institute,
led by Dr. Michael Mullan, is a private non-profit institute
which specializes in research into diseases of the mind.
My direct supervisor at the Roskamp
Institute is Dr. Daniel Paris. We are specifically
looking into the effects of the ß-amyloid peptide
on angiogenesis. For this we are employing numerous
different in-vitro and in-vivo assays aiming to determine
the mechanism(s) of action of the ß-amyloid peptide
in the cerebrovasculature.
Please find below selected publications in this area
of research.
Paris D, Townsend K, Quadros A, Humphrey J, Sun J,
Brem S, Wotoczek-Obadia M, DelleDonne A, Patel N, Obregon
DF, Crescentini R, Abdullah L, Coppola D, Rojiani AM,
Crawford F, Sebti SM, Mullan M. Inhibition of angiogenesis
by Abeta peptides. Angiogenesis. 2004;7(1):75-85.
Patel NS, Paris D, Mathura V, Quadros AN, Crawford
FC, Mullan MJ. Inflammatory cytokine levels correlate
with amyloid load in transgenic mouse models of Alzheimer's
disease. J Neuroinflammation. 2005 Mar 11;2(1):9.
Paris D, Ait-Ghezala G, Mathura VS, Patel N, Quadros
A, Laporte V, Mullan M. Anti-angiogenic activity of
the mutant Dutch A(beta) peptide on human brain microvascular
endothelial cells. Brain Res Mol Brain Res. 2005 May
20;136(1-2):212-30.
Paris, D., Quadros, A., Patel, N., DelleDonne, A.,
Humphrey, J., Mullan, M. 2005. Inhibition of angiogenesis
and tumor growth by beta and gamma-secretase inhibitors.
Eur J Pharmacol. 2;514(1):1-15.
Effect of wild type Aß1-40 and Dutch Aß1-40
on the formation of capillary like networks by human
brain microvascular endothelial cells. Representative
microscopic fields (4X magnification) showing the formation
of network of capillary structures following treatment
with different doses of freshly solubilized wild type
and Dutch Aß1–40.
Figures taken from: Paris D. et al. 2005.
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