Alginate Genes - Conflicts
& Contradictions
Alginate production in P. aeruginosa appears to be under a
complex regulatory control and the genes are located in several regions
of the chromosome. The complexity extends to the nomenclature as well.
Hence here is my feeble attempt to help readers who are interested in P. aeruginosa alginate literature.
Alginate Genes: A
to Z
alg genes |
Alternate designations
|
Location |
Function |
References |
|
algA
|
pmi, manA
|
34'
|
Phosphomannose isomerase and GDP-D-mannose phoshorylase |
( 3, 1, 10, 48, 53)
|
|
algB
|
TG
|
9'
|
Two-component response regulator |
(25, 28, 29, 57) |
|
algC
|
algB, pmm, gmp
|
10'
|
Phosphomannoglucomutase and Biosynthesis of O-side chains in LPS |
(8, 27, 44, 46, 53, 59, 61)
|
|
algD
|
gmd
|
34'
|
GDP-mannose dehydrogenase |
(9, 13, 14, 46) |
|
algE
|
alg76
|
34'
|
Porin-like membrane protein involved in alginate transport (54
kDa) |
(7, 9, 45, 55) |
|
algF
|
TG
|
34'
|
Mannuron acetylase |
(21, 54) |
|
algG
|
TG
|
34'
|
C5-mannuronate epimerase |
(6, 20) |
|
algH
|
TG
|
ND
|
Involved in NdK regulation |
(49) |
|
algI
|
TG
|
34'
|
Involved in acetylation |
(22) |
|
algJ
|
TG
|
34'
|
Involved in acetylation |
(22) |
|
algK
|
kinB
|
9'
|
Histidine Kinase, the environmental sensor, located immediately
downstream of algB |
(35, 43) |
|
algL
|
TG
|
34'
|
Gene immediately downstream of alg8 |
(1, 31) |
|
algM
|
mucC
|
68'
|
Positive regulator, part of Sigma-22 operon;Alternatively, a negative
regulator! |
(4, 5, 43) |
|
algN
|
mucB
|
68'
|
Negative regulator, part of Sigma-22 operon; A periplasmic protein. |
(26, 39, 40, 51, 58) |
|
algO
|
TG
|
DS
|
|
|
|
algP
|
algR3
|
13'
|
Highly basic histone-like protein |
(15, 33) |
|
algQ
|
algR2
|
13'
|
Small Acidic Polypetide, a possible protein kinase |
(34, 32, 47) |
|
algR
|
algR1
|
13'
|
Two-component response regulator |
(9, 16, 12) |
|
algS
|
TG
|
68'
|
Used to designate the switch region at 68' |
(18, 19, 42) |
|
algT
|
algU
|
68'
|
Sigma factor (s22) |
(17, 18, 30, 37, 40, 50, 52, 51, 58) |
|
algU
|
algT
|
68'
|
Sigma factor (s22) |
(17, 18, 30, 37, 40, 50, 52, 51, 58) |
|
algV
|
TG
|
DS
|
|
|
|
algW
|
TG
|
ND
|
HtrA-like protease |
(4) |
|
algX
|
alg60
|
34'
|
|
(9, 41, 55) |
|
algY
|
mucD
|
68'
|
Negative regulator, HtrA-like protease, part of Sigma-22 operon |
(4, 43) |
|
algZ
|
TG
|
ND
|
AlgT-dependent DNA-binding protein required for algD transcription. |
(2) |
|
algZ
|
fimS
|
13'
|
Gene upstream of the response regulator algR ; FimS is required
for twitching motility |
(56, 60) |
ND - Not Determined; DS - this gene Does
not Exist; TG - Thank God there is none
Other Alginate Genes
|
alg8
|
TG
|
34'
|
Membrane-bound protein (41 kDa) |
(9, 36, 55) |
|
alg44
|
TG
|
34'
|
Membrane-bound protein |
(9, 36, 55) |
|
mucA
|
TG
|
68'
|
Anti-sigma factor, a membrane-bound protein; Located downstream
of algT/algU; |
(23, 24, 38, 40, 51, 58) |
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