General Biochemistry
Fall -
2008
Lectures -
MWF 2:00-2:50 PM VH 131
PreTest
and Study Guide
Lecture Links (below) are to Handouts. Example OLD
EXAM.
| Instructor | Phone | Office hours | |
| John Makemson |
makemson@fiu.edu |
305-348-3097 |
OE 246/7: MTWTh 11:00 to Noon
and Friday mornings |
Tentative Syllabus
Lecture PowerPoint figures (or Exam Answers and Scores) are available by clicking on the lecture topic for that day. They are all in pdf format. I
| 25 M | Biological
Logic and Cell Structure |
Ch 1 | Finish End of Chapter Practice Problems.
These exercise your control of units and simple math.
Remember: a number is meaningless without units. Always remember
that answers
on exams without units get zero points. Numbers are meaningless without
units. DO THESE PROBLEMS NOW Solutions
Chapter 1 Problems |
| 27 W | Water,
pKa, Buffers |
Ch 2 | End of Chapter Problems here are like that on
the Exam...know them NOW. Solutions
Chapter 2 Problems |
| 29 F |
Water, pKa, Buffers Exam 1 |
Ch 2 | Exam 1 during the last 25 minutes of the lecture; 50 points |
| Sept |
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|
1 M |
Labor Day Holiday |
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| 3 W |
Amino Acids | Ch 3 |
Problem set exercises not only amino
acid chemistry, but sequencing proteins. Solutions
to Chapter 3 Problems |
| 5 F |
Amino acids, Protein sequencing con't. | Ch 3 |
|
| 8 M |
Proteins 3-D Structure | Ch 4 |
Problem
set here is excellent. You need
to
know these well before lectures on Protein Function and Enzymes. |
| 10 W | Protein Structure+ Review |
Ch4 |
|
| 12 F |
Exam 2 |
Exam 2, 100 points, bring non-graphing
calculator. Integrates material from Chapter 2 |
|
| 15 M |
Protein Function | Ch 5 |
Hemoglobin and
Myoglobin are the models for
changes of protein strcuture and biological
activity/relevance. Solutions |
| 17 W |
Enzymes | Ch6 |
Start the problems now, you need to know how to make Michaelis-Menton and Lineweaver-Burk plots: the exam will have you do these! Knowing how to graph is simple and necessary! Problems Solutions |
| 19 F |
Enzymes, con't |
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| 22 M |
Enzymes, con't |
|
|
| 24 W |
Carbohydrates | Ch7 |
Problems with carbohydrate chemistry and glycosidic links: Get them done NOW!!...and known well before the next exam. |
| 26 F |
EXAM 3 | 100 points. You need to bring: No 2.
Pencils, Simple
Scientific Calculator+ Straight Edge (ruler), This exam
integrates material fromChapters 3 and 4. Exam Key and
Distribution After the Exam Please read course policies about CALCULAOTRS |
|
| 29 M |
Nucleic Acids | Ch 8 |
Problem
set is great with nucleotide
and DNA/RNA. |
| Oct |
|||
| 1 W |
Nucleic Acids, con't |
Ch 8 |
|
| 3 F |
Lipids | Ch 10 |
Lipids: fatty acid chemistry and the
nature of complex lipids are essential to membrane structure, fats and
oil chemistry.
Solutions |
| 6 M |
Membranes and Transport | Ch 11 |
Membranes, life would not exist without them...know how to do the problems Now....quick, the exam is coming up. . |
| 8 W |
Membranes |
|
|
| 10 F |
Exam 4 |
100 points, integrates material from Chapter 3
and 6. Be sure to bring your calculator. |
|
| 13 M |
Biosignalling | Ch 12 |
Biosignalling is a membrane based system and
phospho-relays. We will not cover everything in the chapter, just
the essentials that relate to the metabolic pathways coming up
later. Know these well, it will help later. Solutions
|
| 15 W |
Biosignalling |
|
|
| 17 F |
Biosignalling, Bioenergetics | Ch 12+13 |
Bioenergetics is simple and striaghtforward,
you
did all this in General Chem, we just have to make some modifications
for Biochem. All the pathways we will cover next relies upon
knowing how enzymes work (Chpt 6) and their bioenergetics. Problems |
| 20 M |
Bioenergetics |
Ch13 |
|
| 22 W |
Bioenergetics, Pathways |
||
| 24 F |
EXAM 5 | Integrates material from Ch 3, 5, 6, 7, 8. Be sure to bring your calculator. | |
| 27 M |
Glycolysis, Gluconeogenesis and Pentose Phosphate Pathway | Ch 14 |
Yes, you have to know perfectly the chemistry
of
these pathways...practice as often as you can....these are Central
Metabolism and all pathways come back to them...they are used
throughout the rest of the course. Solutions |
| 29 W |
Glyconeogenesis, PPP |
||
| 31 F |
Citric Acid Cycle | Ch 16 |
This is the other Central Metabolism
pathway...we will use it extensively in the following chapters.
You
need to know it perfectly NOW. Problem
solutions |
| Nov |
|||
| 3 M |
Glucose and Glycogen Regulation | Ch 15 |
All major concepts of pathway regulation are
here. We will be doing them in modified forms for all other
pathways. It is essentail that you can solve the problems
now...it makes the rest so much easier! Solutions |
| 5 W |
Ch 14,15,16 |
Ch 15-16 |
|
| 7 F |
Exam 6 |
100 points. Be sure to bring your
calculator. |
|
| 10 M |
Amino
acid oxidation Fatty acid oxidation |
Ch 17+18 |
Not Here we go...do the problems and see how Beta-oxidation has parallels to the Citric Acid Cycle besides energizing it! Problem set is very helpful. What you need to concentrate on is how nitrogen is dealt with, knowing the Urea cycle perfectly, and generalities of amino acid degradation pathways. Chapter 17 Solutions Chapter 18 Solutions |
| 12 W |
Fat and AA oxidation |
||
| 14 F |
Oxidative Phosporylation | Ch 19 |
All that NADH and FADH2 ends up
here.
Redox chemistry will be practiced (review Chpt 13) and the
various poisons of respiration. Solutions-19 |
| 17 M |
Photophosphorylation | Ch19 |
Electron transport energized by
light.
The
problem set is great, as well as knowing photosynthetic electron flow
and diversity. |
| 19 W |
Carbohydrate Biosynthesis | Ch 20 |
We did glycogen synthesis
earlier (Chpt 15), now
we get to the other major polysaccharides. This is easy if you
already know carbohydrate structure (Chpt 7) and sugar metabolism (Chpt
14 and 15).
Solutions |
| 21 F |
Ch 20 |
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| 24 M |
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| 26 W |
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| 27-30 |
Thanksgiving Holiday, Gobble
Gobble or Oink, Oink |
||
| Dec |
|||
| 1,3,5 |
Problem Solving |
||
| 8-11 |
Final EXAM | Set by Exam Schedule |
Comprehensive. 200 points. After: the graded Exam can be picked up outside OE246. There will be a key and grade distribution on the bulletin board |